Wild card Caroline Wozniacki, another former champion and returning mother, will play 20th seed Magda Linette.
Novak Djokovic missed two of this year's four Grand Slams due to not being vaccinated against the novel coronavirus but the Serbian said he has no regrets about his decision.
Goran Ivanisevic, Djokovic's coach, was greeted with jeers from fans when he broke the news courtside.
Novak Djokovic described Carlos Alcaraz as like facing a blend of the big three -- himself, Rafa Nadal and Roger Federer.
As a sporting spectacle Alcaraz and Djokovic matches have delivered on every level and would be worthy of the Big Apple spotlight.
Danish teenager Holger Rune fought back from a set down to beat hot favourite Novak Djokovic 3-6, 6-3, 7-5 and win his first Masters title in Paris on Sunday.
Novak Djokovic also surpassed Rafael Nadal to make a record 77 Masters 1000 semi-final appearances.
Djokovic's coach Goran Ivanisevic said after the final that the world number one battled the injury
Novak Djokovic secured a semi-final place at the ATP Finals with a 6-3, 6-2 victory over Russian Andrey Rublev on Wednesday, his 50th match win of the year, while Stefanos Tsitsipas withdrew from the tournament due to an elbow injury.
Novak Djokovic produced a stunning performance to thrash Frances Tiafoe in his first match since winning Wimbledon in July to edge Team Europe ahead in the Laver Cup on Saturday.
'I'm just glad to overcome today's challenge in straight sets and move on.'
Reigning Paris Masters champion Novak Djokovic beat Stefanos Tsitsipas in a three-set epic on Saturday to set up a title clash with Holger Rune, who reached his first ATP Masters 1000 final after a comfortable win over Felix Auger-Aliassime.
Novak Djokovic has so far declined to disclose whether he is vaccinated and his father told Serbia's TV Prva that governing body Tennis Australia's stance on players being vaccinated was tantamount to "blackmail".
Only 28 players have ever held the top rank in the ATP Rankings' history, including Djokovic. For the eighth time in a row (he also won the title in 2011-12, 2014-15, 18 and 20), he concluded the year as the top player.
Jannik Sinner began his bid to retain the ATP Finals title with a resounding 7-5, 6-1 win over injury-hit Canadian Felix Auger-Aliassime in their round-robin clash.
Unvaccinated players are not barred from participating in Wimbledon
In the ongoing Monte Carlo Masters, Jannik Sinner clinched a hard-fought win as Casper Ruud crashed out.
Djokovic was deported on the eve of the 2022 Australian Open in January
'He was a better player I think in important moments.'
Fans are buzzing over the prospect of a rematch between world number one Alcaraz and second seed Djokovic in a potential New York finale
Novak Djokovic split with his long-time coach Marian Vajda at the end of the 2021 season, ending one of tennis's most enduring and successful partnerships, the Serbian former world number one said.
No 'triple bagel' but Djokovic thumps Mannarino to reach quarters
Rafael Nadal called Novak Djokovic's COVID-19 vaccination controversy in Australia "a circus" and joked that he would prefer that the world number one tennis player didn't play at the upcoming Australian Open.
Novak Djokovic's bid for a record 21st major title that would have completed the calendar-year Grand Slam collapsed at the final hurdle in a stunning 6-4, 6-4, 6-4 defeat by Russian Daniil Medvedev in the US Open final on Sunday.
Greece's Tsitsipas battled back from 3-5 down in the third set to eliminate Medvedev with a 6-3, 6-7(11), 7-6(1) win to set up a showdown on Friday with Rublev for the Red Group's other semi-final spot.
Australian Open organisers have issued a reminder to players and their entourages about their policy on "inappropriate flags" after a video emerged showing Novak Djokovic's father posing for pictures with fans holding Russian flags.
IMAGES from Day 6 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Saturday.
Images from the men's singles semi-finals at the US Open semi-finals, at Flushing Meadows, New York, on Friday.
Novak Djokovic subdued Jannik Sinner at Wimbledon, easing into a record 35th Grand Slam final.
Spanish teenager Carlos Alcaraz came from behind to beat world number one Novak Djokovic 6-7(5), 7-5, 7-6(5) to reach the Madrid Open final, where on Sunday he will face Alexander Zverev after the German defeated Stefanos Tsitsipas 6-4, 3-6, 6-2.
Factbox on Spanish second seed Carlos Alcaraz, who beat Italian world number one Jannik Sinner 4-6, 6-7(4), 6-4, 7-6(3), 7-6(10-2) in the French Open final on Sunday to win his fifth Grand Slam title.
Novak Djokovic's father Srdjan said on Friday he would not attend his son's Australian Open semi-final and would instead "watch from home".
Novak Djokovic marched into the semis of the Dubai Tennis Championship, with a comfortable win over Hubert Hurkacz.
Novak Djokovic's erratic form, Rafael Nadal's fitness woes and untimely injuries to top-ranked youngsters have set up an uncertain French Open men's tournament
Novak Djokovic said he does not know if will play the grasscourt season after tumbling out of the French Open on Tuesday.
Djokovic will next face Sinner in what will be his 46th Grand Slam semi-final, equalling the record of eight-time champion Roger Federer.
Carlos Alcaraz will aim to reinforce his status as the new all-court monarch of men's tennis with a third successive Wimbledon title
Djokovic unsuccessfully applied to the US government for special permission to play at Indian Wells and Miami.
Djokovic stated that he and Kohli have known each other for a few years
Novak Djokovic defended his father after a video emerged showing him posing at the Australian Open with some fans holding Russian flags, saying he was "misused" by the individuals and that his family was against war.